Value of plasma alpha‑ and beta‑synuclein levels in the diagnosis, severity, and functional outcome of acute ischemic stroke

Özge Başak Fırtına1(0000‑0002‑5464‑1351), Ömer Salt2, Mustafa Burak Sayhan3(0000‑0002‑1156‑5424), Ilker Dibirdik4, Aykut Yucal3

1Department of Emergency Medicine, Mardin Public Hospital, Mardin, Turkey
2Department of Emergency Medicine, Kayseri City Hospital, Kayseri, Turkey
3Department of Emergency Medicine, Trakya University School of Medicine, Edirne, Turkey
4Department of Medical Biochemistry, Trakya University School of Medicine, Edirne, Turkey

Keywords: Acute ischemic stroke, diagnosis, emergency department, Modified Rankin Scale, outcome, synuclein

Abstract

OBJECTIVE: We aimed to determine the role of plasma alpha and beta synuclein levels and other routine inflammatory parameters in the diagnosis, outcome, and mortality of acute ischemic stroke (AIS).

METHODS: In our study, serum alpha and beta synuclein levels and clinical data were prospectively evaluated in 93 subjects (43 controls and 50 AIS patients) admitted to the emergency department. The outcome status and prognostic classification were performed according to the modified Rankin Scale (mRS) scores on the 30th day from hospital admission.

RESULTS: The mean age of the subjects was 70.6 ± 11 years. Thirty eight percentage were female. Plasma α synuclein levels in the AIS group (33.6 ± 8.5 ng/mL) were significantly higher than those in the control group (4.22 ± 2.1 ng/mL) (P < 0.001). Plasma β synuclein levels in the AIS group (13.07 ± 2.7 ng/mL) were significantly higher than those in the control group (2.17 ± 1.4 ng/mL) (P < 0.001). There was no significant difference in alpha and beta synuclein levels between the subgroups formed according to the 30th day results of the patients using the mRS scores (P = 0.813 and 0.812, respectively).

CONCLUSION: The serum alpha and beta synuclein concentrations of patients with AIS at admission were significantly higher than the healthy control group. At admission, serum alpha and beta synuclein levels do not have definitive clinically predictive value in predicting stroke progression and outcome in patients with AIS.

How to cite this article: Fırtına ÖB, Salt Ö, Sayhan MB, Dibirdik I, Yucal A. Value of plasma alpha- and beta-synuclein levels in the diagnosis, severity, and functional outcome of acute ischemic stroke. Turk J Emerg Med 2024;24:238-44.