Acute coronary syndrome developed after vincristine administration

Serkan Öztürk; Davut Baltacı; Selim Ayhan; Mehmet Yazıcı; Ayhan Sarıtaş

doi:10.5505/1304.7361.2011.68725

Serkan Öztürk¹, Davut Baltacı², Selim Ayhan¹, Mehmet Yazıcı¹, Ayhan Sarıtaş³

¹Abant Izzet Baysal University, Faculty Of Medicine, Department Of Cardiology
²Duzce University, Faculty Of Medicine, Family Medicine
³Duzce University, Faculty Of Medicine, Emergency Department

Keywords: Vincristine, doxorubicin, atrio-ventricular block, myocardial infarction.

Abstract

Vincristine and doxorubicin are among the most effective chemotherapeutic agents used in the treatment of malignancies in combination per protocols. However, these chemotherapeutic agents possess great risk for development of cardiotoxicity. The most common manifestations of cardiotoxicity due to use of those chemotherapeutic agents are arrhythmias, systolic dysfunction, cardiomyopathy, pericardial injury and myocardial ischemia. We present a case of acute coronary syndrome with complete atrio-ventricular (AV) block, developed after vincristine and doxorubicin chemotherapy in a patient with multiple myeloma and no cardiac history.