Gastroprotective Effects Of Intragastric L-arginine In Ethanol-induced Gastric Mucosal Injury In Rats | 2004, Volume 4, Issue 3

Levent Avşaroğulları¹, E. Sözüer, Ö. Canöz, C. Yıldırım, İ. İkizceli, Y. Yavuz

¹Erciyes Üniveristesi Tıp Fakültesi, Acil Tıp Anabilim Dalı, Kayseri
²Erciyes Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Kayseri
³Erciyes Üniversitesi Tıp Fakültesi, Patoloji Ad, Kayseri
⁴Gaziantep Üniveristesi Tıp Fakültesi, Acil Tıp Anabilim Dalı, Gaziantep
⁵Afyon Kocatepe Üniversitesi Tıp Fakültesi Acil Tıp Anabilim Dalı, Afyon

Abstract

Study Objectives: The aim of this study is to investigate the gastro protective effects of intragastric L-arginine administration on gastric mucosal integrity in ethanol-induced gastric mucosal injury in rats.
Methods: A total of 30 Wistar albino rats were divided into three groups consisting of ten rats. The rats in the group 1 were given 1.5 mL saline orogastrically. The rats in the group 2 were administered 1.5 mL of 100% ethanol orogastrically. After 60 minutes, the animals were sacrified and the stomachs were removed in both of two groups. L-arginine (100 mg/kg) was diluted with saline to a volume of 1 mL and then administered orogastrically to the rats in the group 3. The rats in this group received 1.5 mL of 100% ethanol orogastrically 30 minutes after the administration of L-arginine. After 60 minutes, the animals were sacrificed and the stomachs were removed.
Results: Macroscopic and microscopic examination showed that a statistically significant reduction of damage occurred in group 3 when compared with group 2 and rapid epithelization occurred in group 3.
Conclusion: The results suggest that orogastrically administered L-arginine may have gastroprotective effect in ethanol-induced gastric mucosal injury.