Grayanotoxin Poisoning

Abstract

Grayanotoxin intoxication occurs by honey ingesting made from Rhododendron species. This honey is also called mad honey. Grayanotoxin shows its effects by binding to the sodium channels in the cell membrane. Symptoms of poisoning are dose dependent. In small doses paresthesia, low blood pressure and bradycardia develop. In severe toxicities altered mental status, seizure, AV block and ventricular tachycardia may occur. So far, most of grayanotoxin intoxication was reported from Turkey. Although there hasn’t been seen any death in humans, grayanotoxin intoxication has to be regarded because of its cardiovascular and respiratory effects.